synthetic bone graft substitutes


cyclOS granules and preforms are synthetic, osteoconductive, resorbable and biocompatible bone substitutes made of beta-tricalcium phosphate (β-TCP, [Ca3(PO4)2]). The macro- and microporous and interconnected structure allow vascularization and bone ingrowth into the bone substitute. 1, 2


cyclOS bone substitutes are intended to be use for filling bony voids or gaps of the skeletal system (spine, trauma, craniomaxillofacial, orthopaedics, osteosynthesis). cyclOS bone substitutes are indicated for use as bone void filler in non-load-bearing areas regions requiring cancellous rather than cortical bone material.

cyclOS granules are versatilely used. cyclOS preforms can be shaped intraoperatively using a scalpel to fit the bone defect. cyclOS Putty is intraoperatively prepared by adding a liquid component such as physiological solution, autologous blood or bone marrow aspirate. The b-TCP granules in the Putty are thus embedded in the hyaluronic acid carrier. The cyclOS Putty is ready in 2 minutes and can be kneaded into the desired shape.



  • Synthetic β-TCP
  • Osteoconductive structure due to macro-, micro- and interconnected porosity 2
  • Remodelling into vital bone within 6–18 months by cellular activity 3, 4
  • Added value by mixing with autologous blood or bone marrow or bone 5, 6
  • AAvailable as granules, preforms and kneadable putty

1 Lu JX et al., Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci Mater Med. 1999;10(2):111-20.

2 Eggli PS et al., The role of pore size on bone ingrowth and implant substitution in hydroxyapatite and tricalcium phosphate ceramics a histologic and morphometric study in rabbits." Biomaterials and Clinical Applications, 1987:53-56.

3 van Hemert WL Et al., Tricalcium phosphate granules or rigid wedge preforms in open wedge high tibial osteotomy: a radiological study with a new evaluation system. Knee. 2004;11(6):451-456.

4 Gaasbeek RD et al., Mechanism of bone incorporation of beta-TCP bone substitute in open wedge tibial osteotomy in patients. Biomaterials. 2005;26(33):6713-6719.

5 Stoll T, Maissen O, Meury T, Becker S. New aspects in osteoinduction. Materialwiss Werkstofftech 2004;35:198-202.

6 Becker S et al., Osteopromotion by a beta-tricalcium phosphate/bone marrow hybrid implant for use in spine surgery. Spine (Phila Pa 1976) 31(1): 11-17.

*3-6: chronOS, todays trademark of DePuy Synthes


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